Everything You Need to Know About PDE5 Inhibitors
If you have spent some time browsing online pharmacies, and paid attention to the descriptions of certain drugs, you might have noticed that some are classified as PDE5 inhibitors. PDE5 does not sound like a term the common man needs to know, as it resembles a chemical formula of some sort, yet the prevalence of PDE5 drugs will surely surprise you, and perhaps convince you to expand your vocabulary. This article will help you learn what PDE5 inhibitors are and what they are good for.
PDE5 is the shortened version of cGMP-specific phosphodiesterase type 5, an enzyme with a very peculiar function. PDE5 is found in the retina, tissues of the penis, and in the smooth muscle of the lungs, and plays a vital role in the cardiovascular system. While the enzyme is mostly beneficial, it also promotes the degradation of the nucleotide cGMP, which regulates blood flow to the penis. Thus, PDE5 inhibitors are drugs that counteract this effect, improving blood flow to the area. Due to the presence of PDE5 in the lungs, inhibitors are also known to counteract another health problem that sometimes affects them.
Uses for PDE5 inhibitors
Treating erectile dysfunction. Erectile dysfunction is a health problem that affects adult men and makes it difficult or impossible for them to achieve an erection during sexual activity. Although erectile dysfunction is most commonly seen as a problem of the elderly, it can occur in many age groups and has many direct and contributing causes:
- Cardiovascular disease
- Multiple sclerosis
- Effects of surgery
- Drug side effects
- Use of SSRI drugs
- Excessive drinking
- Narcotics use
- Kidney failure
- Cavernosal disorders
- Psychological issues
Other uses. PDE5 inhibitors are also officially used to treat pulmonary arterial hypertension, a lung disease. People with pulmonary hypertension experience a rise in blood pressure in the pulmonary vein, artery, and capillaries. In the short term, this causes dizziness, leg swelling, shortness of breath, and fainting, but over time, more severe effects can occur. For example, the left ventricle of the heart may fail, causing blood vessels in the lungs to fill up with liquid. PDE5 inhibitors have also been used unofficially to fight altitude sickness, jet lag, and to improve sports performance.
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The most common and popular PDE5 inhibitors sold today are Viagra, Cialis, and Levitra.
Viagra (sildenafil citrate) is a highly popular drug sold all over the world. Known as “the little blue pill,” it was the first effective treatment for erectile dysfunction introduced to the market, becoming a huge hit. The sildenafil compound was created by a team of researchers working at a pharmaceutical facility in the 1990’s. The drug was intended to be a treatment for angina pectoris (heartburn) but proved only moderately effective. However, many of the male angina test subjects reported getting erections after taking the drug, and some even asked for samples to take home. Researchers were fascinated with this unexpected development and opted to modify the drug for a new purpose. In 1996, Viagra was approved by the FDA, and the drug quickly became a huge success, selling millions of units and prompting various Viagra Pharmacy vendors to appear.
Cialis (Tadalafil) is another drug of this category and with similar indications. Despite being approved in 2003 (nearly 7 years after Viagra), Cialis was also a big hit and remains so to this day. Cialis can be used to treat erectile dysfunction, pulmonary arterial hypertension, and symptoms of benign prostatic hyperplasia.
Levitra (Vardenafil) was developed in 2003 and is quite similar to the previous two drugs mentioned. It is also used to treat erectile dysfunction but has also been known to improve the condition of men who experience premature ejaculation.
PDE5 inhibitor drugs are in high demand, but many people still lack information on how to get them. While some choose to visit their local pharmacy and pay a hefty price, other people get the same product from online stores. For example, you can get Levitra from Canada at a reasonable price if you choose a trusted online vendor like ours.
News by Canadian Pharmacy Mall – www.acanadianhealthcaremall.com