Hello dear readers! We conducted an exclusive research on sexual health and want to share this information with you. Only with us! Exclusive article. Effect of non-steroidal antiandrogens on sexual interest and function Nilutamide Published clinical experience with nilutamide monotherapy is limited to a single open uncontrolled study in which 26 patients with metastatic prostate […]
Antibiotics: Sulphonamides Sulphasalazine Sulphasalazine has been used in the treatment of inflammatory bowel disease since 1942, although the first reports of sperm toxicity only appeared in 1979. Sulphasalazine is taken orally and reaches the colon intact. As a result of the action of colonic bacteria, the compound is split into its constituents sulphapyridine and 5-aminosalicylic […]
Miscellaneous hormones Bromocriptine Bromocriptine is a dopamine agonist widely used in the treatment of hyperprolactinaemia. This disorder is characterised by amenorrhoea and galactorrhoea in women and impotence in males. Infertility is a common presentation of hyperprolactinaemia. Therapy with bromocriptine is generally highly effective in suppressing the elevated prolactin levels and this is associated with a […]
Progestogens Until recently, natural progesterone could not be administered orally as it was broken down in the gastrointestinal tract. Micronised progesterone preparations are now available in some countries but synthetic progestogens are the most widely used. They are divided into two groups. The testosterone analogues include norethisterone, norgestrel and the norgestrel derivatives, i.e. desogestrel, norgestimate […]
The aPTT should be measured approximately 6 h after the bolus dose of heparin, and the continuous IV dose should be adjusted according to the result. Various heparin dose-adjustment nomograms have been developed (Tables 4 and 5), but none are applicable to all aPTT reagents, and, for the reasons discussed above, the therapeutic range should be adapted to the responsiveness of […]
The American College of Cardiology recommends a heparin bolus of 60 to 70 U/kg (maximum dose, 5,000 U) and the infusion of 12 to 15 U/kg/h (maximum dose, 1,000 U per hour) for unstable angina and non-ST-segment elevation myocardial infarction (MI), and somewhat lower dosing (60 U/kg bolus [maximum dose, 4,000 U], and 12 U/kg infusion (maximum dose, 1,000 U per […]
AMP Challenge Airway responsiveness to AMP was assessed using a standardized dosimetric method, as described in detail previously. AMP (Sigma Chemical; St. Louis, MO) was dissolved freshly in 0.9% saline solution to produce a doubling concentration range of 0.39 to 400 mg/mL. Each solution was administered from a jet nebulizer attached to a breath-activated dosimeter (model MB3; Mefar; Brescia, […]
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