Airway Responsiveness to Adenosine 5′-Monophosphate and Exhaled Nitric Oxide Measurements
AMP Challenge Airway responsiveness to AMP was assessed using a standardized dosimetric method, as described in detail previously. AMP (Sigma Chemical; St. Louis, MO) was dissolved freshly in 0.9% saline solution to produce a doubling concentration range of 0.39 to 400 mg/mL. Each solution was administered from a jet nebulizer attached to a breath-activated dosimeter (model MB3; Mefar; Brescia, […]
